Yes, you can use your Jaybird Tarah Pro earbuds for Skype calls or other audio and music applications on your PC and Mac. You will need to pair and connect your Tarah Pro earbuds to your computer before using these. Once connected, you may need to select your earbuds as the default playback and output device in the audio settings of your computer’s operating system. Refer to your computer’s user manual on how to do this.